Speaking on the Tuesday, November 5, episode of her “ MeSsy ” podcast, cohosted with Jamie-Lynn Sigler, who also suffers from the autoimmune disease, Applegate, 52, said she feels sharp pains “every single day.”

The "Married... With Children" alum also revealed that the disease has "traveled into my hands" and makes it difficult to pick up objects.

Christina Applegate has opened up about her agonizing struggles with multiple sclerosis (MS), sharing the raw realities of living with the chronic disease. See details.

Christina Applegate isn't letting her battle with multiple sclerosis stop her from casting her vote. The actress went to vote in Los Angeles, joining various other celebrities who cast their votes on Tuesday.

The actress revealed that her symptoms have “traveled into my hands” as she continues to struggle with multiple sclerosis

Christina Applegate is opening up about what she deals with during her struggles with the condition multiple sclerosis.

Christina Applegate has found herself "screaming" in pain amid her struggles with multiple sclerosis. The 52-year-old actress was diagnosed with the autoimmune disease, which affects her central nervous system,

Christina Applegate, who was diagnosed with multiple sclerosis (MS) in 2021, shared new insight into her experience with the disease, saying, “I can’t even pick up my phone sometimes.”