Israel and Iran exchange missile attacks for a third day; nuclear sites hit, death tolls rise, airspace shut, U.S. warns Tehran against retaliation.

Israeli Iron Dome air defense system fire to intercept missiles over Tel Aviv as others explode and traces fly over Jerusalem during a missile attack by Iran in retaliation for deadly Israeli attacks on nuclear sites and military leaders.

Missiles and projectiles were seen in the skies over Jerusalem and Tel Aviv early on Sunday as Tehran unleashed a fresh attack on Israel which in turn launched an expanded assault on Iran.

Most of those confirmed dead were women and children, according to the authorities, although they have yet to publicly name the victims.

JERUSALEM (Reuters) -Woken by air raid sirens, hurrying to bomb shelters, scouring travel sites for escape routes — thousands of tourists in Israel have found their holiday plans upended by the country's conflict with Iran.

Israel unleashed a punishing barrage of strikes across Iran Sunday stretching from the west to Tehran and Mashhad in the east, after Prime Minister Benjamin Netanyahu vowed to make the country pay "a very heavy price" for killing civilians.

DUBAI — Israel unleashed airstrikes across Iran for a third day Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program, which could provide an offramp, were canceled.

Onlookers gathered on Saturday at a central Tel Aviv residential building next door to Israel’s defense headquarters that was damaged after it took a hit from what appeared to be shrapnel from an overnight missile barrage from Iran.