Cushing syndrome, which is also called Cushing’s syndrome, is a disorder that happens when your body makes too much of the stress hormone cortisol over a long period of time, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Schumer, 43, opened up about “the internet coming for her” swollen face in 2024 press appearances during a “Call Her Daddy” podcast episode on Wednesday, January 22. At first, she tried to brush off the insults until “doctors [started] chiming in in the comments.”