Arachidonic acid is released from cellular membranes in response to allergens and pro-inflammatory stimuli by phospholipase Aâ‚‚. Once freed, it is metabolised through cyclooxygenase (COX), lipoxygenase ...
Cyclooxygenases (COX-1 and COX-2) lie at the heart of the inflammatory cascade, catalysing the conversion of arachidonic acid into bioactive prostaglandins that mediate pain, fever and vascular ...
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