One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...

Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play. T cells, the top agents in this system, survey the internal environment ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...

The immune system may learn not to attack the body by using a small but representative sample of the body’s own protein ...

Researchers from the University of Birmingham have uncovered a completely new mechanism by which fat cells (adipocytes) control how they store and release fat. The results of the study change our ...

Acting as armor, a scaffold and a communication platform in one, our cells' plasma membrane lies at the heart of many crucial cellular processes. Traditionally, it has been thought to function through ...

Adhesion G protein-coupled receptors have a large extracellular region (shown in green and orange) that extends into space outside the cell. Almost 35% of drugs approved by the Food and Drug ...

Alzheimer's disease can develop not only due to the accumulation of beta-amyloid, but also due to a molecular malfunction that disrupts the functioning of neural circuits at an early stage of the ...

Cell surface interactions and receptor dynamics underpin every stage of immune function, from antigen recognition to effector responses. At the plasma membrane, receptors such as the T cell receptor ...

A team created the first systematic catalog of 267 cullin–RING ligase substrate receptors, and 93 are already linked to ...