How a tryptophan-rich allosteric communication network helps activate a major drug target receptor

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...
The Scientist

G Protein-Coupled Receptors and Their Role as Drug Targets

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...
ascopubs.org

Training, Validation, and Test of Deep Learning Models for Classification of Receptor Expressions in Breast Cancers From Mammograms

Long-Term Outcomes in a Multicenter, Prospective Cohort Evaluating the Prognostic 31-Gene Expression Profile for Cutaneous Melanoma A developing data set and a test data set were generated from ...

Light-activated medicines may cut side effects: How a switchable beta blocker works

Rendering a drug effective or ineffective in a flash at the appropriate location—this is the focus of research in photopharmacology. The goal is to develop drugs that can be switched on and off with ...
Drug Target Review

Why NMDA receptor modulation remains central to next-generation depression therapies

Explore NMDA receptor modulation and its critical role in neuronal development and cognitive functions like learning and memory.
EurekAlert!

Better understanding of bitter taste receptors: An AlphaFold3-based structure study

Bitter taste receptors are not only expressed in oral cavity cells but also in the gastrointestinal lining. To understand the diverse functions of these receptors, understanding the structure is ...