For her Ph.D. at VUB and KULeuven, Aarushi Caro created a kind of systematics for dendritic cells, a special group of immune cells in the fight against cancer. Until now, there was a lot of confusion ...

Potential autoimmune diseases therapies that target dendritic cells aim to either inhibit immunogenic dendritic cell functions or support their tolerogenic potential (Figure 2). Most strategies ...

DOC1021 is a first-in-class, patient-derived double-loaded dendritic cell therapy that combines tumor lysate and amplified tumor-derived mRNA. The immunotherapy is made with a patient's dendritic ...

Dendritic cells (DCs) are among the first immune sentinels to detect viruses, bacteria, or other challenges. These specialized messengers alert T cells while orchestrating either a measured calm or a ...

Dendritic cells (DCs) serve as pivotal sentinels of the immune system, bridging innate and adaptive responses by processing and presenting antigens to T cells. Their inherent versatility enables them ...

Pelareorep treatment drives coordinated immune activation and tertiary lymphoid structure formation Translational data suggest potential to boost ...

The immune system must be able to quickly attack invaders like viruses, while also ignoring harmless stimuli, or allergies can result. Immune cells are known to ignore or "tolerate" molecules found on ...

The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. A balance between immunity and tolerance is required as any disturbance ...