The Los Angeles Rams have a big battle set with the Seattle Seahawks, and here is fantasy football start 'em, sit 'em advice for Week 16.

When the Los Angeles Rams and Seattle Seahawks kick off Week 16 on Thursday, they’ll make history as one of the best prime-time matchups ever. It’s the first time two teams with at least 11 wins will play on Thursday Night Football, showing just how rare it is for there to be a game this meaningful on TNF.

In Week 1, the Seahawks lost 17-13 to the 49ers, and in that game, both Darnold and Jaxon Smith-Njigba fumbled the ball away in the fourth quarter. In Week 5, the Seahawks lost 38-35 because their defense couldn't stop Baker Mayfield, who threw for 379 yards. In Week 11, the Seahawks lost to the Rams because Darnold threw four interceptions.

The Rams (11-3) and Seahawks (11-3) battle for the NFC West. Check our NFL odds series for the Rams-Seahawks prediction and pick.

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The playoff picture is becoming clearer. The Los Angeles Rams look to be the team to beat in the NFL, Trevor Lawrence and the Jacksonville Jaguars may be hitting their stride at the right time and Tampa Bay Buccaneers fans breathed a huge sigh of relief when their NFC South rivals,

The Rams can cross Arch Manning off their list of QB targets in 2026 after it was announced that he will return to Texas for next season.