New hantavirus sequencing tool maps whole genomes from hard-to-test samples

Infections by hantaviruses are rare but dangerous, killing 30–40% of infected people. When cases occur, public health officials need rapid, detailed information about the virus to identify the strain ...
Medical Xpress

Single-cell RNA sequencing maps immune cell heterogeneity in mice with allogeneic cardiac transplantation

Immune cells play important roles in mediating allograft rejection and tolerance after cardiac transplantation. However, immune cell heterogeneity at the single-cell level, and how immune cell states ...
Fred Hutch

Circling back to RNA sequencing data to map recursive splice sites

The human genome is just over 6 feet 8 inches long, which is 2 inches taller than the average NBA basketball player and in total, a lot of nucleotides! But what if the amount of sequence diversity ...
Nature

An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing

Motor enzymes that interact with DNA are essential for replicative biological processes. In nanopore sequencing, a motor enzyme controls the motion of a nucleic acid through a protein nanopore, and ...
Nature

Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection

We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the ...
News Medical

Single-cell sequencing maps immune changes in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by BCR-ABL1 gene fusion. The immune microenvironment, implicated in relapse and drug resistance, poses significant challenges ...
technologynetworks

Genomics Tools Help Uncover the Cellular Dynamics of the Aging Brain

While much is mysterious about the aging process, change over time remains its cornerstone. The biological shifts that accompany aging seemingly occur in many cells in the body. The problem is, we ...