Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart. Altered Nav1.5 function is ...

Sodium channels are implicated in many serious conditions such as heart disease, epilepsy and pain, making them an important potential target for drug therapies. Unfortunately, there is still much ...

The results of a new study using mice and heart muscle cells from rabbits have provided a potential molecular explanation for the abnormally rapid heartbeats known as ventricular tachyarrhythmias (VTs ...

Scientists now have a better picture of how voltage-gated sodium (Na v) channels interact with certain animal toxins, thanks to structures solved with cryo-electron microscopy. These channels are ...