A new review argues that periodontitis is driven less by bacteria than by the plasticity and instability of CD4+ T helper cells, whose conversion into hybrid IL-17-producing states fuels inflammatory ...

Cytokine signaling underlies the differentiation, activation and function of T helper (Th) cells, which orchestrate adaptive immunity. Naïve CD4+ T cells adopt specialised fates—Th1, Th2, Th17 or ...

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...