The Tennessee Titans, led by quarterback Cam Ward, face the San Francisco 49ers, led by quarterback Brock Purdy, on Sunday, Dec. 14, 2025 at Levi’s Stadium in Santa Clara, Calif.

The 9-4 San Francisco 49ers look to remain hot as they return home fresh off their bye week to take on the Tennessee Titans. The Titans are coming off their second win of the season, and although they're having a losing season,

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

The 29-year-old leads the team in rushing and receiving, so losing him would be something the 49ers don't even want to consider. Currently dealing with a back issue, the former No. 8 overall pick is still expected to play.

Christian McCaffrey was a late addition to the injury report, but it appears as though the San Francisco 49ers star running back will play despite the back issue.

The San Francisco 49ers made a final decision on wide receiver Brandon Aiyuk after a standoff cost him the 2025 season.

The future of Brandon Aiyuk with the 49ers seems to have hit a critical juncture. This decision marks an unexpected twist in the career of the talented player, who hasn't set foot on the field since his injury in 2022.