Objectives To evaluate the performance of large language models (LLMs) in risk of bias assessment and to examine whether ...

Seeding trials —clinical studies designed primarily for marketing rather than scientific advancement—pose underappreciated risks to research integrity and patient safety. Sukhun Kang and colleagues ...

Objectives Alteplase is commonly recommended for acute ischaemic stroke within 4.5 hours after stroke onset. The Third European Cooperative Acute Stroke Study (ECASS III) is the only trial reporting ...

Objectives To assess the effects of digital patient decision-support tools for atrial fibrillation (AF) treatment decisions in adults with AF. Study design Systematic review and meta-analysis.

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group (RRMG). Rapid reviews (RRs) use modified systematic review (SR) methods to accelerate the review ...

Correspondence on ‘Less is more for patients, practitioners, public and planet: a taxonomy for the harms of too much medicine’ ...

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Correspondence to Professor J. David Spence, Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, ON, N6G 2V4, Canada; dspence{at}robarts.ca ...

6 Key Laboratory of Evidence Based Medicine of Gansu Province, Lanzhou, China Evidence-based medicine (EBM) has developed rapidly since its introduction in a landmark 1992 JAMA paper.1 Professor ...

3 Instituto de Investigación Sanitaria de Canarias (IISC), Tenerife, Spain 4 Fundación Instituto de Investigación Sanitaria de Canarias (FIISC), Tenerife, Spain Objectives Observing Patient ...

This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RR) use modified systematic review methods to accelerate the review process ...

Healthcare delivery is being transformed by the rapid growth of data, advancements in artificial intelligence (AI) and other technologies. In healthcare, obtaining real-world data can be ...