The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and physiological ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. CD8 + T cells have critical roles in tumor ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. T‐box family transcription factors have ...
The fission yeast cell‐polarity regulator tea1p is targeted to cell tips by association with growing microtubule ends. Tea1p is subsequently anchored at the cell cortex at cell tips via an unknown ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Auxin dictates root architecture via the Auxin ...
Contact of developing sensory organs with the external environment is established via the formation of openings in the skin. During eye development, eyelids first grow, fuse and finally reopen, thus ...
Heterozygous DT40 cells with one TRX‐2 allele disrupted with TRX‐2–HisR were transfected. DT40 cells were transfected with the indicated plasmids and drug‐resistant clones were analyzed for homologous ...
5′‐AGT CCG CCC TGA GCA AAG A‐3′5′‐TCA CGA ACT CCA GCA GGA CC‐3′.
The spatiotemporal regulation of cAMP can generate microdomains just beneath the plasma membrane where cAMP increases are larger and more dynamic than those seen globally. Real‐time measurements of ...
This month's cover highlights the article Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation by A.-D. Brunner, M. Mann and colleagues. A new ultra-high ...
Taken together, the SPR and crosslinking assays indicate that monomeric Soj directly interacts with DnaA both in solution and bound to DNA, and that the substitutions in the DnaA Sup proteins disrupt ...
Here we describe a new signaling cross‐talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction ...
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