New targeting discovery: Researchers found that DNA sequences can guide methylation machinery, a shift from the belief that only other epigenetic marks directed it. Backup gene control: Even without ...

Scientists have developed SpaMosaic, an AI-driven method to integrate fragmented spatial multi-omics datasets, enabling unified molecular maps across tissues. The tool combines contrastive learning ...

A new computational method could dramatically accelerate efforts to map the body's cells in space, according to a study ...

Abstract: Motivation: Transcription-regulatory elements (TREs) are critical modulators of gene transcription, with promoters and enhancers being major hubs for gene regulation. Of these, enhancers are ...

Archaeology 500-year-old gold dental bridge is earliest known oral care of its kind in Scotland — and it likely held a fake tooth Archaeology 'Lifelong monogamy' and 'half orphans': DNA analysis ...

Epigenetic regulation of gene expression entails DNA methylation and histone modifications, which orchestrate chromatin structure and transcriptional activity. Aberrant regulation of these mechanisms ...

Researchers at the University of Cologne and University Hospital Cologne have determined that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as antibody ...

Before a newly synthesized protein can undergo folding, it must be processed and transported to the correct location within the cell after emerging from the ribosome. N-terminal acetylation ...

Cancer remains one of the most challenging diseases in modern medicine due to its intricate molecular mechanisms. Beyond genetic alterations, epigenetic regulation has emerged as a central determinant ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...