The 49ers square off against the Colts and their newly un-retired quarterback on Monday Night Football in Week 16.

Kyle Shanahan explains the 49ers' pregame roster moves and what Jordan Watkins must do to earn more playing time this season.

Ricky Pearsall is facing another injury setback. He had six catches for 96 yards on Sunday, helping the San Francisco 49ers ...

A week ago, Philip Rivers shocked the NFL when he decided to work out with the Colts amid injuries to quarterbacks Daniel ...

While every other aspect of the Seahawks has ranked among the best in the NFL, the run game remains a work in progress as it ...

Kyle Shanahan provides key 49ers injury updates on Ricky Pearsall, Spencer Burford, Jacob Cowing and others after the win ...

The San Francisco 49ers are trending the right way from a health perspective entering a Week 16 showdown with the Indianapolis Colts.

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

The San Francisco 49ers collected a win on Sunday over the Tennessee Titans in Santa Clara, moving to 10-4 on the season and ...

Brandon Aiyuk and the 49ers have apparently kept their relationship long-distance as a divorce inevitably looms.

The San Francisco 49ers are headed to Indianapolis for a Week 16 matchup against the Colts, and they now officially know who ...

Head coach Kyle Shanahan said Monday that Gross-Matos (hamstring) should return to practice ahead of the 49ers ' Week 16 tilt against the Colts on Monday, Dec. 22, Matt Barrows of The Athletic reports ...