eLife11h
Odors drive feeding through gustatory receptor neurons in Drosophila
In sum, odors initiate feeding behavior in Drosophila.
eLife13h
An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish
This important study shows that in teleost fish, the RIG-I-like protein MDA5 can compensate for the absence of RIG-I by detecting 5'-triphosphorylated RNA. A fish virus containing such RNA can ...
eLife11h
Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity
Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue – an essential ...
eLife19h
Pain Management: A promising alternative to opioids
A complex extracted from the amniotic membrane in humans reduces post-surgical pain in mice by directly inhibiting pain-sensing neurons.
eLife3d
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research
A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
eLife6d
Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...
eLife4d
The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting
A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
eLife3d
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and ...
eLife5d
Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction
This study presents valuable findings from an observational dataset in a riverine ecosystem about the effects of genetic and species diversity, across multiple trophic levels, on ecosystem functions.
eLife6d
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...
eLife7d
Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice
However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...
eLife10d
Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory
Department of Psychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology o ...