Background Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to immune checkpoint blockade, owing to its ...
DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?
We read with great interest the recent study by Lau et al , who reported distinct intrahepatic hepatitis B virus (HBV) ...
Background Endoscopic submucosal dissection (ESD) enables en bloc resection of early gastrointestinal cancers and provides ...
The increasing availability and decreasing costs of DNA sequencing have resulted in the re-grouping of rare, severe paediatric cases of progressive familial intrahepatic cholestasis (PFIC) with more ...
2 Centre for Immunobiology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK 3 University Hospitals Leuven, Department of Gastroenterology and ...
Introduction The principle means of providing analgesia during colonoscopy in the UK is either through conscious sedation, or use of entonox, a fast-acting inhaled and self-administered analgesic gas.
Introduction In a post-biosimilar era, where cost-effectiveness impacts therapeutic choices, filgotinib is an attractive option for UC. Whilst pivotal trial data and short-term real-world studies are ...
Background The classification of IBD into ulcerative colitis (UC) and Crohn’s disease (CD) is based on clinicopathological criteria established in the 20th century. Whether this binary reflects ...
Clinical trials in IBD face difficulties of escalating complexity, high costs and challenges in recruitment. Digital twins are virtual, data-driven replicas of individual patients that model disease ...
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Background CDH1 is commonly mutated in sporadic diffuse gastric cancer (DGC) and germline CDH1 mutations underlie most cases of the cancer syndrome hereditary DGC. Objective We aimed to develop mouse ...
2 School Of Medical Sciences – Universiti Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan, Malaysia 3 Gastrointestinal FunctionandMotiltiy Unit (GiFM) – Hospital Pakar Universiti Sains Malaysia, ...
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