The EMBO Journal6h
p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK ...
The EMBO Journal6h
Cellular senescence, p21, and the path to fibrosis
In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...
The EMBO Journal1d
BATokines in metabolic liver disease: good cops or bad cops?
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et al (2024) identify PCPE-1 as a brown-adipose tissue-derived mediator of ...
The EMBO Journal2d
Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males
Evidence suggests mitochondrial homeostasis plays a role in autism spectrum disorders (ASDs), but the causal relationships ...
The EMBO Journal3d
The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The precise organization of pre- and ...
The EMBO Journal3d
Proteome-wide copy-number estimation from transcriptomics
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein copy numbers constrain systems-level ...
The EMBO Journal3d
A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The intracellular bacterial pathogen Coxiella ...