Sudan's ongoing nationwide conflict has triggered one of the world's worst humanitarian crises, displacing 13·9 million people,1 including more than 4 million individuals who have fled across borders.

Ulcerative colitis is a chronic, immune-mediated disorder of the colon, which is characterised by a relapsing–remitting course. Owing to the growing understanding of the immunopathogenesis of this ...

In 2002, Georges C Benjamin (his father, George, thought the French spelling was “cool”) accepted what he assumed would be a short assignment as Executive Director of the American Public Health ...

Recommendations for Interventional Trials (SPIRIT) 2025 guidelines published in The Lancet and commend the efforts to enhance transparency and rigour in clinical trial protocols.1,2 Accurate and ...

Like many countries in recent years, Kenya has been facing its first mpox epidemic. Clotilde Bigot reports from Mombasa.

Acute kidney injury (AKI) is among the most common organ failures observed in the hospital and can irrevocably alter the trajectory of a patient's short-term and long-term health.1–4 The lack of ...

The 2025–26 respiratory syncytial virus (RSV) season is shaping up to be a pivotal moment in the fight against this significant global health threat. In just the past 2 years, three products have been ...

Immunotherapy—could that be an option for me, doctor?” is a question frequently asked by patients with colorectal cancer. The ...

We show that, compared with surgeon predictions and existing risk-prediction tools, our machine-learning model can enhance ...

With drastic reductions in health aid threatening essential services and millions of lives, WHO issues new guidance for countries to safeguard health budgets, limit out-of-pocket payments, and ...

Emotional distress among adolescents in most participating countries was higher in 2022 than in 2018, with disproportionate ...

Undiagnosed and uncontrolled hypertension remains one of the most important preventable causes of heart attack, stroke, chronic kidney disease, and dementia. In 2024, an estimated 1·4 billion people ...