The San Francisco 49ers host the Tennessee Titans in Week 15 of the NFL season. Follow along for highlights and live score updates.

The Tennessee Titans, led by quarterback Cam Ward, face the San Francisco 49ers, led by quarterback Brock Purdy, on Sunday, Dec. 14, 2025 at Levi’s Stadium in Santa Clara, Calif.

San Francisco 49ers wide receiver Ricky Pearsall was briefly knocked out of Sunday’s game against the Titans by an illegal tackle that wasn’t penalized by the referees.

San Francisco 49ers wide receiver Ricky Pearsall is dealing with an injury in the first quarter of the Week 15 game against the Tennessee Titans.

Cam Ward threw a 34-yard TD to Gunnar Helm that trimmed the Tennessee Titans deficit to 14-10 against the San Francisco 49ers.

Ricky Pearsall injured his knee on a hip drop tackle in Week 15. We break down the news and provide injury updates.

Tennessee Titans rookie tight end Gunnar Helm was having a good day after scoring his second NFL touchdown against the San Francisco 49ers in Week 15, but things are starting to take a turn in the wrong direction.

Brock Purdy threw a 4-yard TD to Jauan Jennings that gave the San Francisco 49ers a 7-0 lead over the Tennessee Titans.

The 49ers face the Titans at home in Santa Clara in Week 15. We break down what the game means for the NFL playoff picture.