Questlove and Boyz II Men will also contribute to the milestone episode.

The Simpsons ‘ 800th episode, titled “Irrational Treasure,” will feature guest voice appearances by Kevin Bacon, Quinta Brunson, Questlove, and stars from HBO Max’s The Pitt.

In the Season 4 Simpsons episode, "The Front," Bart and Lisa read a letter that is implied to have a swear word.

During a guest appearance on Simpsons Declassified with Nancy Cartwright, Matt Mercer discussed what Dungeons & Dragons class best fits Bart Simpson, positing that he would be an excellent bard.

WANE 15 caught up with a Wolcottville man who loves "The Simpsons ahead of the show's upcoming milestone.