EV-SELEX speeds GPCR drug discovery by capturing receptor-bound DNA aptamers

G protein-coupled receptors (GPCRs) are the most abundantly expressed proteins in the human body, regulating diverse ...
FierceBiotech

Ligand tries to disembark from part of Viking pact, alleging contract breach

Viking Therapeutics’ collaboration with Ligand Pharmaceuticals has sailed into some trouble, with one of the partners keen to jettison part of the pact. The two companies’ relationship dates back to ...
Wall Street Journal

Ligand Pharmaceuticals Is Buying Xoma for Nearly $740 Million

Under the terms, Ligand will pay $39 a share in cash for Xoma, a 2.9% premium over the $37.90 closing price on Friday. The deal is expected to close in the third quarter.
Reuters

Ligand Pharma to acquire fellow biotech royalty rights buyer XOMA for $739 million

April 27 (Reuters) - Ligand Pharmaceuticals (LGND.O), opens new tab will buy fellow biotechnology royalty aggregator XOMA Royalty (XOMA.O), opens new tab for about $739 million in cash, the companies ...
FiercePharma

Ligand snaps up fellow biotech royalty aggregator Xoma for $739M

After Xoma Royalty went on a dealmaking spree last year, the biotech royalty aggregator is now itself being bought out by its peer Ligand Pharmaceuticals. On Monday, Ligand announced plans to acquire ...
Seeking Alpha

Ligand Pharmaceuticals: Reliable Midcap Pharma With Perfected High Growth Business Model

Ligand Pharmaceuticals continues to outperform, driven by its high-margin, diversified royalty model and disciplined investment approach. LGND’s transition in 2022 to a capital and technology provider ...
eLife

In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

Department of Chemistry & Biochemistry, Colleges of Science & Medicine, University of Arizona, Tucson, United States Department of Pharmacology & Toxicology, R Ken Coit College of Pharmacy, University ...
eLife

In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
ascopubs.org

Network pharmacology analysis of phytochemicals in targeting cancer: A systems biology approach.

Safety and efficacy of pembrolizumab and epacadostat combination therapy in metastatic epithelial-derived cancers: A systematic review and meta-analysis of randomized controlled trials. Preclinical ...
IEEE

Local–Global Structure-Aware Geometric Equivariant Graph Representation Learning for Predicting Protein–Ligand Binding Affinity

Abstract: Predicting protein-ligand binding affinities is a critical problem in drug discovery and design. A majority of existing methods fail to accurately characterize and exploit the geometrically ...
Scientific Research Publishing

Salmaso, V. and Moro, S. (2018) Bridging Molecular Docking to Molecular Dynamics in Exploring Ligand-Protein Recognition Process: An Overview. Frontiers in Pharmacology, 9 ...

ABSTRACT: Background: The Coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 coronavirus, remains a global threat despite lifting the health emergency. Scientists from all ...