INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

Brock Purdy and the San Francisco 49ers will play the Indianapolis Colts at Lucas Oil Stadium on ESPN on Monday, December 22, ...

The Indianapolis Colts are just trying to get into the playoffs. The San Francisco 49ers are playing for a division title and ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.

This article was originally published on www.si.com/nfl/49ers/onsi as How Brock Purdy's Return Has Shifted the 49ers' Locker ...

One prominent NFL insider named two teams that could potentially be interested in trading for San Francisco 49ers QB Mac ...

Winning 37-24 against the Tennessee Titans required a bunch of pivotal plays for the San Francisco 49ers. The game would've ...

The 49ers re-sign quarterback Adrian Martinez to the practice squad and work out two offensive linemen as they assess roster ...