Week 12 of the 2025 college football season continues on Saturday with 22 of the teams ranked in the latest College Football Playoff Rankings in action. This weekend is shaping up to be one of the best slates of the entire season with four ranked-on-ranked matchups on tap.

The No. 18 Michigan Wolverines, led by quarterback Bryce Underwood, face the Northwestern Wildcats on Saturday, Nov. 15, 2025 at Wrigley Field in Chicago, Ill.

Justice Haynes, Michigan football’s junior running back, will not suit up for the Wolverines against Northwestern on Saturday, Nov. 14 at Wrigley Field. The star ball carrier missed the team’s most recent game against Purdue after suffering a right foot injury late in the contest against Michigan State.

Penn State won the last matchup, 42-0, at Ford Field in 2023. The Nittany Lions are 7-point favorites in the latest Michigan State vs. Penn State odds, while the over/under for total points scored is 49.

No. 18 Michigan football is 7-2 and has a clear opportunity in front of them: If the Wolverines win out, they are likely to secure a spot in the College Footbal

The NCAA put Michigan State’s football program on three years of probation and penalized the school $30,000 plus 1.5% of the team’s budget after agreeing former staff members under coach Mel Tucker broke rules regarding recruiting inducements and benefits,

The SportsLine Projection Model has revealed its Minnesota Golden Gophers vs. Oregon Ducks picks for Friday's Big Ten matchup