HPV cfDNA is a highly effective tumor marker for monitoring disease progression and treatment response in HPV-positive ...

Our understanding of the molecular pathogenesis of LAMA2 -related muscular dystrophy ( LAMA2 -MD) requires improving. Here, we report the phenotype, neuropathology, and transcriptomics data (scRNA-seq ...

An organoid-based screening platform that allows one-gene-at-a-time knockdown across a whole tissue has been used to identify the genes that regulate closure of the neural tube in humans.

Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.

This study offers a valuable theoretical framework for quantifying molecular transport across interfaces between coexisting liquid phases, emphasizing interfacial resistance as a central factor ...

Structural reconstruction of thousands of ancient nitrogenases through Earth’s history uncovers architectural constraints that shaped their evolution under global environmental transitions.

Non-essential amino acids such as glutamine have been known to be required for T cell general activation through sustaining basic biosynthetic processes, including nucleotide biosynthesis, ATP ...

The analysis of neural morphology across Heliconiini butterfly species revealed brain area-specific changes associated with new foraging behaviours. While the volume of the centre for learning and ...

This study provides valuable insights into human valve development by integrating snRNA-seq and spatial transcriptomics to characterize cell populations and regulatory programs in the embryonic and ...

Fully autonomous home-cage training system HABITS enables mice to learn complex cognitive behaviors without human intervention, expanding behavioral paradigms and optimizing training efficiency ...

Uptake of cell-free chromatin particles released from dying cells and carrying non-coding DNA could redefine mammalian genomics.

In 2024, eLife continued with its efforts to make peer review and publishing better for science and scientists.