eLife

Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

Harm and responsibility differentially shape guilt and shame, which in turn drive compensatory behavior to varying extents.
eLife

Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

Exogenous attention is a rapid, involuntary mechanism that automatically reallocates processing resources toward salient stimuli. It enhances visual sensitivity in the vicinity of the salient stimulus ...
eLife

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

An AI-driven computational toolkit, Gcoupler, integrates ligand design, statistical modeling, and graph neural networks to predict endogenous metabolites that allosterically modulate the GPCR–Gα ...
eLife

Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

This valuable study provides solid evidence for deficits in aversive taste learning and taste coding in a mouse model of autism spectrum disorders. Specifically, the authors found that Shank3 knockout ...
eLife

Tuberculosis: A surprising new hiding place for a dangerous pathogen

The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
eLife

A modular platform to display multiple hemagglutinin subtypes on a single immunogen

BOAS is a platform for building multivalent viral protein immunogens without a scaffold, such as a nanoparticle, to elicit broad influenza vaccine responses.
eLife

Timely vaccine strain selection and genomic surveillance improve evolutionary forecast accuracy of seasonal influenza A/H3N2

Reducing vaccine development time from 12 months to 6 reduces forecasting error by 25%, while reducing lags in genome sequence submission reduces uncertainty of current clade frequencies by 50%.
eLife

Evolutionary remodeling of non-canonical ORF translation in mammals

This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse by reanalyzing nearly 400 Ribo-seq datasets using a standardized pipeline; ...
eLife

Microsaccades track shifting but not necessarily maintaining covert visual-spatial attention

This useful study demonstrates that microsaccade direction primarily indexes shifts rather than the maintenance of covert spatial attention, offering a focused interpretation that may help reconcile ...
eLife

Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...
eLife

Neuronal Activity: Keeping track of moving targets

A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.
eLife

Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

This manuscript makes a valuable contribution to the concept of fragility of meta-analyses via the so-called 'ellipse of insignificance for meta-analyses' (EOIMETA). The strength of evidence is solid, ...