Gut

Deciphering the prodrome of inflammatory bowel disease up to 10 years before disease onset by massively parallel serology

Background Defining immune dysregulation during the asymptomatic prodrome of immune-mediated diseases offers opportunities ...
Gut

Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer

Background Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to immune checkpoint blockade, owing to its ...
Gut

DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?

We read with great interest the recent study by Lau et al , who reported distinct intrahepatic hepatitis B virus (HBV) ...
Gut

Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards

Background Endoscopic submucosal dissection (ESD) enables en bloc resection of early gastrointestinal cancers and provides ...
gut.bmj

Large language models for detecting colorectal polyps in endoscopic images—further research is required

We read with great interest the study by Carlini et al on using multimodal large language models (MLLMs), specifically GPT-4o and Gemini 1.5 Pro, to detect colorectal polyps using the SUN database.1 ...
gut.bmj

Pueraria lobata-derived exosome-like nanovesicles alleviate rheumatoid arthritis via targeting Ruminococcus gnavus phenylethylamine production

Background Gut microbiota has been widely recognised as playing a critical role in maintaining immune imbalance and the development of rheumatoid arthritis (RA). As key roles mediating interkingdom ...
gut.bmj

From preclinical phase of Crohn’s disease to postoperative recurrence: shared mechanisms and potential interventions

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with high risk of surgery. Despite advances in medical treatment, of those patients who undergo ileocolonic ...
gut.bmj

Atypical diarrhea in an immunocompetent infant

A 2-month-old male infant was admitted with a 2-day history of cough and fever. Respiratory pathogen testing on admission confirmed influenza A (H1N1) virus infection. The patient was started on oral ...
gut.bmj

MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk

Background Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and results from pathogenic germline variants affecting mismatch repair. The tissue microenvironment that ...
gut.bmj

Landscape screening identifies the lactate-modifying enzyme AARS2 as a master regulator and therapeutic target in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC), one of the most prevalent cancers worldwide, has a high mortality owing to diagnostic challenges and therapeutic resistance. Lactate metabolism and protein ...
gut.bmj

Digital twins in IBD--bridging data, biology and trial innovation

Clinical trials in IBD face difficulties of escalating complexity, high costs and challenges in recruitment. Digital twins are virtual, data-driven replicas of individual patients that model disease ...
gut.bmj

Clarifying the clinical role and implementation boundaries of the clinical-radiological model for TACE-treated hepatocellular carcinoma

We read with interest the multicentre study by Guo et al, which developed a late-fusion imaging model (LFM) and a clinical-radiological model (CRM) for hepatocellular carcinoma treated with ...