Mepolizumab is a monoclonal antibody that targets interleukin-5, a key cytokine in eosinophilic inflammation. The MATINEE ...
Background Obstructive sleep apnoea (OSA) is a prevalent sleep disorder strongly associated with metabolic syndrome. Visceral ...
Objective Severe early-onset-chronic obstructive pulmonary disease (SEO-COPD) represents the most severe form of COPD that ...
Background In most chronic airway diseases, identifying phenotypes has advanced clinical practice and research. However, no such phenotypes exist for paediatric bronchiectasis. We therefore sought to ...
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A 19-year-old female presented with complaints of cough, dyspnoea and chest pain, which had been ongoing for approximately 2 weeks. On physical examination, the patient was afebrile and ...
A 14-year-old female with constitutional mismatch repair deficiency syndrome and recurrent glioblastoma multiforme was referred for respiratory evaluation due to chronic cough and abnormal chest ...
Establishing the top 10 research priorities for lung volume reduction treatment for people with COPD
Lung volume reduction procedures are an established evidence-based aspect of chronic obstructive pulmonary disease (COPD) care. We conducted a research prioritisation exercise involving people with ...
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Healthy adult lowlanders sojourning above altitudes of 3000 m naturally develop periodic breathing (PB) ~40% of total sleep time (TST) increasing to 100% TST at 8000 m.1 Concerns have been raised that ...
Acute asthma exacerbations remain a major driver of morbidity and hospitalisation, accounting for substantial healthcare utilisation worldwide. Systemic oral corticosteroids (OCS) are the first-line ...
Can targeted combination pharmacotherapy find its mark in the treatment of obstructive sleep apnoea?
The search for an effective drug therapy for obstructive sleep apnoea (OSA) has long been driven by a familiar clinical reality: although positive airway pressure (PAP) remains highly efficacious, ...
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