All News - ALZFORUM
6 days ago · TYPE OF NEWS. Research News (4501) Conference Coverage (1403) Community News (277) Interviews (33) Book Reviews (7) DISEASE. Alzheimer's Disease (3331) Amyotrophic Lateral Sclerosis (541) Parkinson's Disease (476) Frontotemporal Dementia (434) Triplet Repeat Diseases (153) Dementia with Lewy Bodies (115) Progressive Supranuclear Palsy (95 ...
ALZFORUM | NETWORKING FOR A CURE
5 days ago · New Role for Tau: Making Lipid Droplets in Glia? When neurons are overwhelmed by oxidative stress, they spew out peroxidized lipids, which are promptly mopped up by nearby glia. According to new research, tau play a pivotal role in this clean-up. In binding microtubules, it helps lipid droplets bud from the glial endoplasmic reticulum.
Do Two APOE4 Alleles Always Mean Alzheimer's? - ALZFORUM
Tools. 10 May 2024. For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are destined to develop AD. As reported in Nature Medicine on May 6, researchers led by ...
X-Chromosome-Wide Association Data Spot Alzheimer’s Loci
Tools. 25 Sep 2024. About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic foundation for this has been difficult to uncover. Now, two large X-chromosome-wide association studies (XWAS) and a smaller one based on pathologically confirmed AD identify 12 loci that might shed ...
Finally: Big Win on All Outcomes for Lecanemab in Phase 3 Topline ...
Oct 12, 2022 · Alzheimer’s researchers hailed the news as a major advance. In particular, they welcomed the straightforward findings after the highly contested rollout of aducanumab last year. “What the field needed was a clearly positive result from a trial completed and conducted per protocol,” Gil Rabinovici at the University of California, San ...
A New Era of Alzheimer’s Treatment - ALZFORUM
22 Jun 2021. The Food and Drug Administration’s decision to greenlight aducanumab (trade name Aduhelm) for Alzheimer’s disease has touched off an explosion of criticism and debate (see Part 1 of this series). Some researchers, however, consider the approval an overall positive development that the neurodegeneration field can build on as it ...
Alzheimer’s Gene BIN1 Promotes Synaptic Transmission
Mar 18, 2020 · BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and microglial function. Now, in the March 10 Cell Reports, researchers led by Gopal Thinakaran at the USF Morsani College of Medicine in Tampa ...
FDA Will Regulate Diagnostic Tests. Yes, Those for Alzheimer’s, Too.
10 May 2024. For decades, the U.S. Food and Drug Administration has taken a light touch to regulating diagnostic tests that use body fluids or tissues. Such assays, very much including cerebrospinal fluid and blood tests for Alzheimer’s disease, were able to be marketed without providing proof of accuracy in the intended population. Now, the ...
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before …
Tools. 27 Sep 2024. Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are well underway at the protein level. In a study published September 26 in Cell, scientists led by Carlos Cruchaga at Washington University in St. Louis provide further support for this concept.
Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes
Feb 25, 2021 · A meta-analysis in 2013 pulled together 17,000 cases and turned up 19 risk loci, 11 of them new (Oct 2013 news). Geneticists at the International Genomics of Alzheimer’s Project analyzed more than 35,000 cases to find five new loci (Mar 2019 news). A separate effort went broader by including UK Biobank samples from people with family ...