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The joke is that a cell can have the right receptor sitting there ready to respond, but nothing actually happens unless the correct signal molecule binds to it. The receptor being present does not guarantee activation. What I’m saying relates to me as a human being by recognizing that sometimes I can be ready for something, open to something, or built to respond to something, but if the signal never comes, nothing changes. The humor comes from using cell signaling to describe the very specific f
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